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ifnar1 neutralization experiment  (Bio X Cell)


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    Bio X Cell ifnar1 neutralization experiment
    Fig. 5 | IFN-I signaling in T cells drives GzmB production and renal tissue damage. a CD8+ and CD4+ T cells were isolated from the spleen of <t>Ifnar1</t> KO or wild- type mice, and transferred into Rag1 KO mice (WT, n = 8; KO, n = 9). b Representative photographs of PAS staining of the kidney. Quantification is also shown (WT, n = 8; KO, n = 9). Representative histograms and bar graphs showing the MFI of IRF7 in CD8+ T cells (c) and CD4+ T cells (d) isolated from the kidney (WT, n = 8; KO, n = 9). e Representative flow cytometry plots and a bar graph illustrating the production of GzmB in CD8+ T cells (WT, n = 8; KO, n = 9). f Bar graph showing the production of GzmB in CD4+ T cells (WT, n = 8; KO, n = 9). g cGN was induced in mice, and mice were injected with anti-IFNAR1 Ab (n = 10) or isotype control (n = 9)
    Ifnar1 Neutralization Experiment, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 96/100, based on 256 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ifnar1+neutralization+experiment/pm40393992-280-2-13?v=Bio+X+Cell
    Average 96 stars, based on 256 article reviews
    ifnar1 neutralization experiment - by Bioz Stars, 2026-07
    96/100 stars

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    1) Product Images from "Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice."

    Article Title: Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice.

    Journal: Nature communications

    doi: 10.1038/s41467-025-59819-7

    Fig. 5 | IFN-I signaling in T cells drives GzmB production and renal tissue damage. a CD8+ and CD4+ T cells were isolated from the spleen of Ifnar1 KO or wild- type mice, and transferred into Rag1 KO mice (WT, n = 8; KO, n = 9). b Representative photographs of PAS staining of the kidney. Quantification is also shown (WT, n = 8; KO, n = 9). Representative histograms and bar graphs showing the MFI of IRF7 in CD8+ T cells (c) and CD4+ T cells (d) isolated from the kidney (WT, n = 8; KO, n = 9). e Representative flow cytometry plots and a bar graph illustrating the production of GzmB in CD8+ T cells (WT, n = 8; KO, n = 9). f Bar graph showing the production of GzmB in CD4+ T cells (WT, n = 8; KO, n = 9). g cGN was induced in mice, and mice were injected with anti-IFNAR1 Ab (n = 10) or isotype control (n = 9)
    Figure Legend Snippet: Fig. 5 | IFN-I signaling in T cells drives GzmB production and renal tissue damage. a CD8+ and CD4+ T cells were isolated from the spleen of Ifnar1 KO or wild- type mice, and transferred into Rag1 KO mice (WT, n = 8; KO, n = 9). b Representative photographs of PAS staining of the kidney. Quantification is also shown (WT, n = 8; KO, n = 9). Representative histograms and bar graphs showing the MFI of IRF7 in CD8+ T cells (c) and CD4+ T cells (d) isolated from the kidney (WT, n = 8; KO, n = 9). e Representative flow cytometry plots and a bar graph illustrating the production of GzmB in CD8+ T cells (WT, n = 8; KO, n = 9). f Bar graph showing the production of GzmB in CD4+ T cells (WT, n = 8; KO, n = 9). g cGN was induced in mice, and mice were injected with anti-IFNAR1 Ab (n = 10) or isotype control (n = 9)

    Techniques Used: Isolation, Staining, Cytometry, Injection, Control



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    ifnar1 neutralization experiment  (Bio X Cell)
    96
    Bio X Cell ifnar1 neutralization experiment
    Fig. 5 | IFN-I signaling in T cells drives GzmB production and renal tissue damage. a CD8+ and CD4+ T cells were isolated from the spleen of <t>Ifnar1</t> KO or wild- type mice, and transferred into Rag1 KO mice (WT, n = 8; KO, n = 9). b Representative photographs of PAS staining of the kidney. Quantification is also shown (WT, n = 8; KO, n = 9). Representative histograms and bar graphs showing the MFI of IRF7 in CD8+ T cells (c) and CD4+ T cells (d) isolated from the kidney (WT, n = 8; KO, n = 9). e Representative flow cytometry plots and a bar graph illustrating the production of GzmB in CD8+ T cells (WT, n = 8; KO, n = 9). f Bar graph showing the production of GzmB in CD4+ T cells (WT, n = 8; KO, n = 9). g cGN was induced in mice, and mice were injected with anti-IFNAR1 Ab (n = 10) or isotype control (n = 9)
    Ifnar1 Neutralization Experiment, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ifnar1+neutralization+experiment/pm40393992-280-2-13?v=Bio+X+Cell
    Average 96 stars, based on 1 article reviews
    ifnar1 neutralization experiment - by Bioz Stars, 2026-07
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    Fig. 5 | IFN-I signaling in T cells drives GzmB production and renal tissue damage. a CD8+ and CD4+ T cells were isolated from the spleen of Ifnar1 KO or wild- type mice, and transferred into Rag1 KO mice (WT, n = 8; KO, n = 9). b Representative photographs of PAS staining of the kidney. Quantification is also shown (WT, n = 8; KO, n = 9). Representative histograms and bar graphs showing the MFI of IRF7 in CD8+ T cells (c) and CD4+ T cells (d) isolated from the kidney (WT, n = 8; KO, n = 9). e Representative flow cytometry plots and a bar graph illustrating the production of GzmB in CD8+ T cells (WT, n = 8; KO, n = 9). f Bar graph showing the production of GzmB in CD4+ T cells (WT, n = 8; KO, n = 9). g cGN was induced in mice, and mice were injected with anti-IFNAR1 Ab (n = 10) or isotype control (n = 9)

    Journal: Nature communications

    Article Title: Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice.

    doi: 10.1038/s41467-025-59819-7

    Figure Lengend Snippet: Fig. 5 | IFN-I signaling in T cells drives GzmB production and renal tissue damage. a CD8+ and CD4+ T cells were isolated from the spleen of Ifnar1 KO or wild- type mice, and transferred into Rag1 KO mice (WT, n = 8; KO, n = 9). b Representative photographs of PAS staining of the kidney. Quantification is also shown (WT, n = 8; KO, n = 9). Representative histograms and bar graphs showing the MFI of IRF7 in CD8+ T cells (c) and CD4+ T cells (d) isolated from the kidney (WT, n = 8; KO, n = 9). e Representative flow cytometry plots and a bar graph illustrating the production of GzmB in CD8+ T cells (WT, n = 8; KO, n = 9). f Bar graph showing the production of GzmB in CD4+ T cells (WT, n = 8; KO, n = 9). g cGN was induced in mice, and mice were injected with anti-IFNAR1 Ab (n = 10) or isotype control (n = 9)

    Article Snippet: For the IFNAR1 neutralization experiment, we injected 100μg of InVivoMAb anti-mouse IFNAR-1 antibody (BioXCell, BE0241) or InVivoMAb anti-mouse IgG1 isotype control antibody (BioXCell, BE0083) on days 0, 3, 6, and 9 of the cGN.

    Techniques: Isolation, Staining, Cytometry, Injection, Control